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|Tested species reactivity||Chicken, Human|
|Published species reactivity||Xenopus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is predicted to react with mouse and rat based on sequence homology.
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells.
PA5-13348 was used in western blot to demonstrate that peptide hormone prolactin activates sodium and chloride transport in renal epithelial cells via ENaC and ClC4
|Greenlee MM,Mitzelfelt JD,Duke BJ,Al-Khalili O,Bao HF,Eaton DC||American journal of physiology. Renal physiology (308:F697)||2015|
chloride channel 4; Chloride channel protein 4; chloride channel, voltage-sensitive 4; Chloride transporter ClC-4; ClC-4; CLCN4; H(+)/Cl(-) exchange transporter 4
ClC-4; ClC-4A; CLC4; CLCN4