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Invitrogen
CLEC4B Monoclonal Antibody (349214)
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Product Details
MA5-24089
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
349214
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse DCAR/CLEC4B Gln42-Leu209
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610616
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The CLEC4B gene encodes a member of the C-type lectin domain family and plays a significant role in immune system regulation, particularly involving the activation and modulation of neutrophils. CLEC4B is expressed in various immune cells, including neutrophils, where it contributes to controlling inflammatory responses and immune activation. It has been identified as a regulator of bystander activation of autoreactive and potentially pathogenic T cells, suggesting its involvement in limiting chronic inflammation. This gene participates in glycan recognition, which can induce the production of reactive oxygen species, thereby protecting tissues from oxidative stress and inflammatory damage. The role of CLEC4B extends to the regulation of neutrophil availability and function, exerting additive effects with other genes to modulate immune responses. CLEC4B's function in immune homeostasis presents potential therapeutic implications, particularly in autoimmune diseases and conditions involving excessive inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen presenting cell lectin-like receptor A2; C-type lectin domain family 4, member b1; dendritic cell immunoactivating receptor
Gene Aliases: 1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2; DCARbeta
Entrez Gene ID: (Mouse) 69810
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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