UCK1 (Uridine-cytidine kinase 1) phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. This enzyme does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Of note, UCK1 is able to use either ATP or GTP as a phosphate donor. UCK1 also possesses the ability to phosphorylate a number of cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
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Protein Aliases: CK; CMK; CMPK; CMPK1; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Cytidine monophosphate kinase; Cytidylate kinase; cytidylate kinase 1; dCMP kinase; Deoxycytidylate kinase; likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK); Nucleoside-diphosphate kinase; UMK; UMP-CMP kinase; UMP/CMP kinase; UMP/CMPK; UMPK; uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase
Gene Aliases: 0610011D08Rik; CK; CMK; CMPK; CMPK1; UCK; UMK; UMP-CMPK; UMPK