Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CNCalpha4, CNG5; CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide-gated cation channel alpha 4; Cyclic nucleotide-gated cation channel alpha-4; Cyclic nucleotide-gated channel alpha-4; Cyclic nucleotide-gated olfactory channel subunit OCNC2; OCNC2; olfactory cyclic nucleotide-gated channel
Gene Aliases: Cgn2; Cnga4; rOCNC2