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|Tested species reactivity||Human, Rat, Rabbit|
|Host / Isotype||Goat / IgG|
|Immunogen||Recombinant, full length human CNTF protein expressed in E. coli.|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1 µg/ml|
|Inhibition Assays (IA)||120 ug/ml|
|Neutralization (Neu)||120 µg/ml|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24825 detects CNTF from human samples. PA1-24825 is expected to cross react with rat (85% conserved) and rabbit (85% conserved) due to sequence homology.
PA1-24825 has been successfully used in neutralization, inhibition assays, and Western blot procedures. Neutralization: The ND50 is 120 ug/ml.
The PA1-24825 immunogen is recombinant, full length human CNTF protein expressed in E. coli.
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ciliary neurotrophic factor; ciliary neurotropic factor