Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:1,000 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
GT473 |
Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human COL11A2. The exact sequence is proprietary. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2735152 |
Positive Control: human COL11A2-transfected 293T cells (N-terminal fragment of COL11A2 isoform 1)
Predicted Reactivity: Mouse (85%), Rat (85%), Bovine (93%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Collagen alpha-2(XI) chain; collagen, type XI, alpha 2; DAQB-79P13.8; HGNC:2187; pro-a2 chain of collagen type XI; procollagen, type XI, alpha 2; type XI collagen alpha2 chain
Gene Aliases: COL11A2; DFNA13; DFNB53; FBCG2; HKE5; PARP; STL3
UniProt ID: (Human) P13942, (Mouse) Q64739
Entrez Gene ID: (Human) 1302, (Mouse) 12815, (Rat) 294279
Molecular Function:
extracellular matrix structural protein
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