Collagen IV is a major constituent of the basement membranes along with laminins and enactins. Collagen IV is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio. Collagen IV can form insoluble fibers with high tensile strength. Antibody to collagen IV is useful in detecting the loss of parts of basement membrane in carcinomas.
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Protein Aliases: Canstatin; Collagen alpha-2(IV) chain; procollagen, type IV, alpha 2
Gene Aliases: Col4a-2; COL4A2; ICH; POREN2