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|Tested species reactivity||Human|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG1|
|Immunogen||Human cartilage derived COMP|
|Storage buffer||tissue culture supernatant diluted in 0.2M tris HCl, pH 7.4, with 5-10% FBS|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||Assay dependent|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-20221 detects COMP in human samples.
MA1-20221 has been successfully used in ELISA, immunoprecipitation, immunohistochemistry (frozen and paraffin) and Western blot applications. Predicted molecular weight 82.8 kDa.
The MA1-20221 immunogen is human cartilage derived COMP.
COMP is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Control of organization and function of muscle and tendon by thrombospondin-4.
MA1-20221 was used in immunohistochemistry to study the role of thrombospondin-4 in the function of skeletal muscle and tendon using knockout mice
|Frolova EG,Drazba J,Krukovets I,Kostenko V,Blech L,Harry C,Vasanji A,Drumm C,Sul P,Jenniskens GJ,Plow EF,Stenina-Adognravi O||Matrix biology : journal of the International Society for Matrix Biology (37:35)||2014|
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; MED; MGC131819; MGC149768; PSACH; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); THBS5; thrombospondin-5
COMP; EDM1; EPD1; MED; PSACH; THBS5; TSP5