JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
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Protein Aliases: 38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; MGC3149; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Gene Aliases: COPS5; CSN5; JAB1; MOV-34; SGN5
UniProt ID: (Human) Q92905
Entrez Gene ID: (Human) 10987
Molecular Function: translation initiation factor