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MA5-17060 targets COTL1 in IHC, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17060 immunogen is purified recombinant fragment of human COTL1 expressed in E. Coli.
MA5-17060 detects COTL1 which has a predicted molecular weight of approximately 16kDa.
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: coactosin-like 1; coactosin-like F-actin binding protein 1; Coactosin-like protein; FLJ43657; MGC19733
Gene Aliases: CLP; COTL1
UniProt ID: (Human) Q14019
Entrez Gene ID: (Human) 23406
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