PA5-16318 targets COX-1 in IHC (P) applications and shows reactivity with Human samples.
The PA5-16318 immunogen is synthetic peptide corresponding to C-terminal of human COX-1.
Cyclooxygenases 1 and 2 (COX-1, COX-2) are enzymes involved in the conversion of arichidonate to prostaglandins. COX-1 and COX-2 are very similar in structure and function, though they vary in expression. COX-1 is normally expressed in most cell types, whereas COX-2 expression is at low levels unless induced by hormonal stimuli. In some breast cancer and bladder carcinoma studies, COX-1 was expressed in the stroma cells adjacent to the tumors but not in tumor cells.
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Protein Aliases: COX-1; Cyclooxygenase-1; PGH synthase 1; PHS 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene Aliases: Cox-1; Cox-3; COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1