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Product Details
PA5-104519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human COX11(Accession Q9Y6N1), corresponding to amino acid residues S60-S110.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853820
Product Specific Information
Antibody detects endogenous levels of total COX11.
Target Information
Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein necessary for the construction of an active COX complex. COX11 contains a single transmembrane helix downstream of the N-terminal, mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain. The assembly of COX requires the delivery of metal cofactors. Along with COX12 and SCO1/2, COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COX11 cytochrome c oxidase copper chaperone; COX11 homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly homolog 11; cytochrome c oxidase assembly protein 11; Cytochrome c oxidase assembly protein COX11, mitochondrial; cytochrome c oxidase subunit 11
Gene Aliases: 2010004I09Rik; COX11; COX11P
UniProt ID: (Human) Q9Y6N1, (Mouse) Q6P8I6
Entrez Gene ID: (Human) 1353, (Mouse) 69802, (Rat) 690300
Performance Guarantee
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