The antibody detects endogenous levels of total COX18 protein.
COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain. Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COX18 cytochrome c oxidase assembly factor; COX18Hs; cytochrome c oxidase assembly homolog 18; Cytochrome c oxidase assembly protein 18; Cytochrome c oxidase assembly protein COX18, mitochondrial; OXA1L2
Gene Aliases: COX18; COX18HS; OXA1L2
UniProt ID: (Human) Q8N8Q8
Entrez Gene ID: (Human) 285521
Molecular Function: transporter