PA1-20955 detects COX2 in Human samples.
PA1-20955 has been successfully used in Immunohistochemistry (Paraffin) procedures. For use in IHC-P, boil tissue sections in 10mM citrate buffer, p.H. 6.0 for 10 minutes followed by cooling at room temp for 20 minutes.
PA1-20955 immunogen corresponds to Synthetic peptide corresponding to the C-terminal region of rat COX2.
Predicted to react with mouse and rat.
COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COII; COX-2; cyclooxygenase 2; cyclooxygenase 2b; Cyclooxygenase-2; MTCO2; PGH synthase 2; PHS II; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene Aliases: COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2; PTGS2
UniProt ID: (Human) P35354
Entrez Gene ID: (Human) 5743