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|Tested species reactivity||Human|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the C-terminal region of rat COX2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA1-20955 detects COX2 in Human samples.
PA1-20955 has been successfully used in Immunohistochemistry (Paraffin) procedures. For use in IHC-P, boil tissue sections in 10mM citrate buffer, p.H. 6.0 for 10 minutes followed by cooling at room temp for 20 minutes.
PA1-20955 immunogen corresponds to Synthetic peptide corresponding to the C-terminal region of rat COX2.
Predicted to react with mouse and rat.
COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dual contradictory effect of H-89 on neuronal retraction, death and inflammation in differentiated PC12 cells subjected to oxidative stress.
PA1-20955 was used in western blot to study the effects of a selective PKA inhibitor on cell death and inflammation of PC12 cells under conditions of oxidative stress
|Alamdary SZ,Digaleh H,Khodagholi F||Journal of molecular neuroscience : MN (51:1030)||2013|
COII; cyclooxygenase 2; cyclooxygenase 2b; MTCO2; PGH synthase 2; PHS II; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2; PTGS2