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Invitrogen
COX7A2/COX7A3 Polyclonal Antibody
FIGURE: 1 / 5
COX7A2/COX7A3 Antibody (PA5-99611) in ICC/IF
Immunofluorescent analysis of COX7A2/COX7A3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and COX7A2/COX7A3 polyclonal antibody (Product # PA5-99611) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fl... View More
Product Details
PA5-99611
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human COX7A2P2(Accession O60397), corresponding to amino acid residues L5-H55.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2818544
Product Specific Information
Antibody detects endogenous levels of total COX7a2/3.
Target Information
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. COX7A2 is predicted to enable electron transfer activity, to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation, and to be part of mitochondrial respiratory chain complex IV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytochrome c oxidase polypeptide 7A2, mitochondrial; cytochrome c oxidase polypeptide VIIa-liver/heart; Cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa polypeptide 2 (liver); Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart; cytochrome c oxidase subunit VIIaL; cytochrome c oxidase, subunit 7a 3; cytochrome c oxidase, subunit VIIa 2; hepatic cytochrome-c oxidase chain VIIa
Gene Aliases: COX7A2; Cox7a3; COX7AL; COX7AL1; COXVIIa-L; COXVIIAL; VIIAL
UniProt ID: (Human) P14406, (Rat) P35171, (Mouse) P48771
Entrez Gene ID: (Human) 1347, (Rat) 29507, (Mouse) 12866
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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