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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues K(68) K R K K K S S E T F L S E L A E I(85) C of rat CPP-binding protein.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||1:600|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA3-106 detects the CPP-binding protein.
PA3-106 has been used successfully in Western blot, ELISA, immunoprecipitation, immunohistochemistry, and immunocytochemistry procedures. In Western blot analysis of rat brain synaptic membranes this antibody detects ~80 kDa and ~60 kDa proteins representing CPP-binding protein. The ~60 kDa protein is likely a breakdown product of the ~80 kDa CPP-binding protein.
The PA3-106 immunogen is a synthetic peptide corresponding to residues (68)K K R K K K S S E T F L S E L A E I(85) C of rat CPP-binding protein.
CPP is a potent antagonist acting selectively at NMDA type excitatory amino acid receptors. This compound is more potent than previously reported NMDA antagonists in depressing mammalian spinal neuronal responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cloning of a brain N-methyl-D-aspartate- and D, L-epsilon-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653)-binding protein.
PA3-106 was used in western blot to clone and characterize CPP binding protein
|Kumar KN,Johnson PS,Chen X,Pal R,Ahmad M,Ragland T,Bigge C,Michaelis EK||Biochemical and biophysical research communications (253:463)||1998|