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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the C-terminal residues K(396) A E P K R T T L G(405) C of rat CPP-binding protein.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||1:600|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Gel Shift (GS)||See 1 publications below|
PA3-107 detects the CPP-binding protein.
PA3-107 has been used successfully in Western blot, ELISA, immunoprecipitation, immunohistochemistry, and immunocytochemistry procedures. In Western blot analysis of rat brain synaptic membranes this antibody detects ~80 kDa and ~60 kDa proteins representing CPP-binding protein. The ~60kDa protein is likely a breakdown product of the ~80 kDa CPP-binding protein.
The PA3-107 immunogen is a synthetic peptide corresponding to the C-terminal residues K(396) A E P K R T T L G(405) C of rat CPP-binding protein.
CPP is a potent antagonist acting selectively at NMDA type excitatory amino acid receptors. This compound is more potent than previously reported NMDA antagonists in depressing mammalian spinal neuronal responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
PA3-107 was used in EMSA assay to investigate the role of HSF-1 in the regulation of Fas ligand transcription
|Bouchier-Hayes L,McBride S,van Geelen CM,Nance S,Lewis LK,Pinkoski MJ,Beere HM||Cell death and differentiation (17:1034)||2010|