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Alomone Labs, LTD

CRF1/CRHR1 (extracellular) Polyclonal Antibody

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CRF1/CRHR1 (extracellular) Polyclonal Antibody

Product Details

ACR-050-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

1:600
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ENLSLTSNVSGLQC, corresponding to amino acid residues 31-44 of rat CRHR1, Extracellular, N-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Amount

170 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor receptor variant 1j; corticotropin-releasing factor type 1 receptor; CRF 1 receptor; Crf receptor 1; Crf type 1; Crf1 receptor; CRF1a-desK; CRF1I; CRH-R1d; type 1 CRH receptor; CRH-R1h; CRHR1c; CRHR1e; CRHR1f; CRHR1g; G protein-coupled receptor; seven transmembrane helix receptor; unnamed protein product

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Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF-R1alpha; CRF1; CRF1R; CRFR-1; CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1; CRHR; CRHR1L

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UniProt ID: (Human) P34998, (Mouse) P35347, (Rat) P35353

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Entrez Gene ID: (Human) 1394, (Mouse) 12921, (Rat) 58959

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Function(s)
transmembrane signaling receptor activity G-protein coupled receptor activity protein binding G-protein coupled peptide receptor activity corticotrophin-releasing factor receptor activity corticotropin-releasing hormone receptor activity corticotropin-releasing hormone binding G-protein alpha-subunit binding peptide binding macromolecular complex binding peptide hormone binding
Process(es)
response to hypoxia cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway memory feeding behavior visual learning hormone-mediated signaling pathway adrenal gland development adult behavior epithelial cell differentiation positive regulation of synaptic transmission, GABAergic negative regulation of epinephrine secretion multicellular organismal response to stress exploration behavior locomotory exploration behavior fear response positive regulation of mast cell degranulation negative regulation of neuron apoptotic process behavioral response to cocaine behavioral response to ethanol regulation of synaptic plasticity behavioral response to pain regulation of transport positive regulation of corticotropin secretion response to electrical stimulus general adaptation syndrome general adaptation syndrome, behavioral process long-term synaptic potentiation cellular response to corticotropin-releasing hormone stimulus positive regulation of cAMP/PKA signal transduction negative regulation of feeding behavior regulation of corticosterone secretion immune response activation of adenylate cyclase activity female pregnancy parturition cellular response to hormone stimulus negative regulation of voltage-gated calcium channel activity hypothalamus development response to immobilization stress positive regulation of secretion by cell
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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