This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Product may be stored at -20C for one year. After reconstitution, at 4C for one month. Product can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
MA5-27879 has been validated to detect CRM1 in rat, mouse, human and canine.
Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chromosome region maintenance 1 homolog; Chromosome region maintenance 1 protein homolog; Exp1; exportin 1 (CRM1 homolog, yeast); exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; Exportin-1; exportin-1 (required for chromosome region maintenance)
Gene Aliases: AA420417; CRM1; emb; Exp1; XPO1
Molecular Function: receptor