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Invitrogen
CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)
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FIGURE: 1 / 9
CSNK1A1/CSNK1A1L Antibody (MA5-56415) in ICC/IF
Immunocytochemistry analysis of CSNK1A1/CSNK1A1L with HCT 116 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp). Next they were incubated with CSNK1A1/CSNK1A1L Recombinant Monoclonal Antibody (Product # MA5-56415)at a dilution of 1:500 in 1% BSA in PBST over... View More
Product Details
MA5-56415
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH04-58
Immunogen
Recombinant protein within human CSNK1A1 aa 1-337/337.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3679470
Target Information
CSNK1A1 (casein kinase 1 alpha 1) and CSNK1A1L (casein kinase 1 alpha 1-like) are serine/threonine protein kinases involved in various cellular processes. CSNK1A1 is located on chromosome 5 (5q32) and functions as a putative tumor suppressor, playing a role in cell cycle regulation, apoptosis, and autophagy. It is involved in the CGAS-STING pathway, inhibiting the overactivation of type I interferon signaling by promoting autophagic degradation of STING1. Additionally, CSNK1A1 has implications in certain cancers and myelodysplastic syndromes where its regulation affects cell proliferation and sensitivity to therapies. In contrast, CSNK1A1L is a paralog of CSNK1A1 that shares similar functional domains and potentially overlapping functions, although its specific role and regulatory mechanisms remain less characterized. Both genes are involved in critical pathways regulating cell survival and immune response, and their dysregulation is associated with disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; casein kinase I-alpha; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p
Gene Aliases: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1; CK1a; CKIa; Csnk1a; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; PRO2975
UniProt ID: (Human) P48729, (Human) Q8N752, (Rat) P97633
Entrez Gene ID: (Human) 1452, (Human) 122011, (Rat) 113927, (Mouse) 93687
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
magnesium ion binding
glycoprotein binding
peptide binding
phosphoprotein binding
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
phagocytosis
Golgi organization
mitotic nuclear division
signal transduction
cell surface receptor signaling pathway
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cell morphogenesis
cell cycle
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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