Sequence of this protein is as follows: MSGVRPPIMN GPLHPRPLVA LLDGRDCTVE MPILKDVATV AFCDAQSTQE IHEKVLNEAV GALMYHTITL TREDLEKFKA LRIIVRIGSG FDNIDIKSAG DLGIAVCNVP AASVEETADS TLCHILNLYR RATWLHQALR EGTRVQSVEQ IREVASGAAR IRGETLGIIG LGRVGQAVAL RAKAFGFNVL FYDPYLSDGV ERALGLQRVS TLQDLLFHSD CVTLHCGLNE HNHHLINDFT VKQMRQGAFL VNTARGGLVD EKALAQALKE GRIRGAALDV HESEPFSFSQ GPLKDAPNLI CTPHAAWYSE QASIEMREEA AREIRRAITG RIPDSLKNCV NKDHLTAATH WASMDPAVVH PELNGAAYRY PPGVVGVAPT GIPAAVEGIV PSAMSLSHGL PPVAHPPHAP SPGQTVKPEA DRDHASDQL
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
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Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684
Gene Aliases: BARS; CTBP; CTBP1
UniProt ID: (Human) Q13363
Entrez Gene ID: (Human) 1487