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CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (PCRP-CTBP2-1A9)

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CTBP2 (C-terminal binding protein 2) Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry/Immunofluorescence analysis of HeLa cells using CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (Product # 1488-MSM1-P1) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red)..

CTBP2 (C-terminal binding protein 2) Antibody in Flow Cytometry (Flow) — Flow Cytometry analysis of PFA-fixed HeLa cells using CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (Product # 1488-MSM1-P1) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

CTBP2 (C-terminal binding protein 2) Antibody in Peptide array (ARRAY) — Analysis of Protein Array containing more than 19,000 full-length human proteins CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (Product # 1488-MSM1-P1). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

CTBP2 (C-terminal binding protein 2) Antibody — SDS-PAGE Analyis Purified CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (Product # 1488-MSM1-P1). Confirmation of Purity and Integrity of Antibody.

Product Details

1488-MSM1-P1

Applications	Tested Dilution	Publications
Immunocytochemistry (ICC/IF)	1-2 µg/mL	-
Flow Cytometry (Flow)	1-2 µg/10^6 cells	-
Peptide Array (Array)	Assay-dependent	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG2b
Class	Monoclonal
Type	Antibody
Clone	PCRP-CTBP2-1A9
Immunogen	Recombinant full-length human CTBP2 protein View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	200 µg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.4, with 0.05% BSA
Contains	0.05% sodium azide
Storage conditions	4° C

Target Information

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-terminal-binding protein 2; CtBP2; ribeye; RP11-59C5.2

Gene Aliases: CTBP2

UniProt ID: (Human) P56545

Entrez Gene ID: (Human) 1488

Molecular Function: transcription cofactor

Function(s)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated negative regulation of cell proliferation viral genome replication positive regulation of chromatin binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of retinoic acid receptor signaling pathway white fat cell differentiation oxidation-reduction process

Process(es)

chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity retinoic acid receptor binding NAD binding

CTBP2 (C-terminal binding protein 2) Monoclonal Antibody (PCRP-CTBP2-1A9)

Product Details

1488-MSM1-P1

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Peptide Array (Array)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Target Information

References (0)

Bioinformatics

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