Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
CF806797
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2C9
Immunogen
Human recombinant protein fragment corresponding to amino acids 27-349 of human CTGF produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; H-CTGF; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839
Gene Aliases: CCN2; CTGF; HCS24; IGFBP8; NOV2
UniProt ID: (Human) P29279
Entrez Gene ID: (Human) 1490
cartilage condensation
ossification
angiogenesis
regulation of cell growth
tissue homeostasis
transcription initiation from RNA polymerase II promoter
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
epidermis development
response to wounding
response to glucose
organ senescence
positive regulation of gene expression
negative regulation of gene expression
cell migration
cell differentiation
lung development
regulation of chondrocyte differentiation
response to estradiol
positive regulation of collagen biosynthetic process
response to anoxia
intracellular signal transduction
chondrocyte proliferation
response to amino acid
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to peptide hormone
positive regulation of cell differentiation
positive regulation of JNK cascade
positive regulation of cell activation
response to mineralocorticoid
positive regulation of stress fiber assembly
cytosolic calcium ion transport
positive regulation of cardiac muscle contraction
negative regulation of cell death
extracellular matrix constituent secretion
positive regulation of G0 to G1 transition
positive regulation of ERK1 and ERK2 cascade
response to fatty acid
DNA biosynthetic process
reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support