This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
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Protein Aliases: cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; homoserine deaminase; homoserine dehydratase
Gene Aliases: CTH
UniProt ID: (Human) P32929
Molecular Function: lyase