This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control for this product is human spleen lysate.
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to T-cell antigen T4 (CD4), to infect target cells. Some G protein-coupled receptors including chemokine (C-C) receptor 5 (CCR5), chemokine (C-X-C) receptor 4 (CXCR4), CCR3, CCR2b, and CCR8 in the chemokine receptor family, and four new human molecules G-protein coupled receptor 15 (GPR15), CXCR6, GPR1, and chemokine (C-X3-C) receptor 1 (CX3CR1) were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR, or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine stromal cell-derived factor-1 (SDF-1) is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlate with HIV-1 permissiveness in diverse human cell types. Some antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
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Protein Aliases: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; CMKBRL1; CMKDR1; CX3C chemokine receptor 1; Fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; GPR13; GPRV28; RBS11; V28
Gene Aliases: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; Rbs11; V28
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor