|Tested species reactivity||Mouse|
|Published species reactivity||Rat, Mouse, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the N-terminus of the mouse CXCR3 protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor (CXCR) 3, a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation.
71-8800 was used in flow cytometry to investigate the immunological mechanism leading to rejection of allogeneic bone marrow-derived stromal cells after implantation in murine central nervous system
|Tambuyzer BR,Bergwerf I,De Vocht N,Reekmans K,Daans J,Jorens PG,Goossens H,Ysebaert DK,Chatterjee S,Van Marck E,Berneman ZN,Ponsaerts P||Immunology and cell biology (87:267)||2009|
|Mouse||Not Cited||Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer.||Sharma S,Yang SC,Zhu L,Reckamp K,Gardner B,Baratelli F,Huang M,Batra RK,Dubinett SM||Cancer research (65:5211)||2005|
|CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung.||Widney DP,Hu Y,Foreman-Wykert AK,Bui KC,Nguyen TT,Lu B,Gerard C,Miller JF,Smith JB||Infection and immunity (73:485)||2005|
|Mouse||Not Cited||Regulation of pulmonary fibrosis by chemokine receptor CXCR3.||Jiang D,Liang J,Hodge J,Lu B,Zhu Z,Yu S,Fan J,Gao Y,Yin Z,Homer R,Gerard C,Noble PW||The Journal of clinical investigation (114:291)||2004|
|Mouse||Not Cited||EBV-induced molecule 1 ligand chemokine (ELC/CCL19) promotes IFN-gamma-dependent antitumor responses in a lung cancer model.||Hillinger S,Yang SC,Zhu L,Huang M,Duckett R,Atianzar K,Batra RK,Strieter RM,Dubinett SM,Sharma S||Journal of immunology (Baltimore, Md. : 1950) (171:6457)||2003|
|Not Applicable||Not Cited||
CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model.
71-8800 was used in immunohistochemistry - paraffin section and western blot to assess the association with poor survival in breast cancer and promotion of metastasis in a murine model due to CXCR3 expression
|Ma X,Norsworthy K,Kundu N,Rodgers WH,Gimotty PA,Goloubeva O,Lipsky M,Li Y,Holt D,Fulton A||Molecular cancer therapeutics (8:490)||2009|