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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (KLH conjugated)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
OPA1-15096 detects CXCR5 from human samples.
OPA1-15096 has been successfully used in immunohistochemistry procedures. By immunohistochemistry (paraffin).
The OPA1-15096 immunogen is a synthetic peptide (KLH conjugated). The epitope has been mapped to the 3rd cytoplasmic domain of human CXCR5.
CXCR5, a Chemokine Receptor, also called Burkitt's lymphoma receptor 1, is required for normal development of Peyer's patches, inguinal lymph nodes and splenic follicles. CXCR5 binds B-lymphocyte chemoattractant (BLC) and is involved in B-cell homing to follicles in lymph nodes and spleen. Two isoforms are produced by alternative splicing. CXCR5 expression has been reported in human blood and salivary gland and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs have been isolated from human brain, germ cell, lung, lymph, pancreas, skin, stomach, and uterus cancer libraries, and from normal human blood, liver/spleen, lymph node, nerve, placenta, small intestine, tonsil, and B-cell/lung/testis libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Blr-1; BLR1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt's lymphoma receptor 1; C-X-C chemokine receptor type 5; CD185 antigen; CXC-R5; CXCR-5; GPR9; MDR-15; MDR15; monocyte-derived receptor 15
BLR1; CD185; MDR15
Signal transduction Cell surface receptor mediated signal transduction G-protein mediated signaling Immunity and defense B-cell- and antibody-mediated immunity Cytokine/chemokine mediated immunity Cell structure and motility Cell motility