This antibody is specific for human Cytochrome b245 light chain aa 29-33 (TAGRF) and 183-188 (PQVNPI). The immunogen was prepared using partially purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification in Triton X-100).
This target has a predicted molecular weight of 21 kDa.
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
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Protein Aliases: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit
Gene Aliases: CYBA; p22-PHOX
UniProt ID: (Human) P13498
Entrez Gene ID: (Human) 1535