|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
|Western Blot (WB)||0.03 - 0.1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (SYLNFARKRIKNP) corresponding to the internal amino acids of CYBB|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine based on sequence homology.
Cytochrome b is composed of cytochrome b alpha and beta chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease . In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CGD; CGD91-phox; CYBB; Cytochrome b(558) subunit beta; cytochrome b-245 beta polypeptide; Cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; cytochrome b-245, beta polypeptide (chronic granulomatous disease); Cytochrome b558 subunit beta; GP91-1; GP91-PHOX; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; Superoxide-generating NADPH oxidase heavy chain subunit
Gene Aliases: AMCBX2; CGD; CYBB; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
UniProt ID: (Human) P04839
Entrez Gene ID: (Human) 1536
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