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FIGURE: 1 / 3
CYFIP1 Antibody (MA5-53852) in ICC/IF
Immunocytochemistry analysis of CYFIP1 in HepG2 cells. Nuclei were stained blue with DAPI; CYFIP1 recombinant monoclonal antibody (Product # MA5-53852) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Product Details
MA5-53852
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB1605
Immunogen
A synthesized peptide derived from human CYFIP1 (50-100AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CYFIP1; Cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; FLJ45151; p140sra-1; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1
Gene Aliases: CYFIP1; E030028J09Rik; KIAA0068; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140SRA-1; P140sra1; pl-1; SHYC; SRA-1; SRA1
UniProt ID: (Human) Q7L576, (Mouse) Q7TMB8
Entrez Gene ID: (Human) 23191, (Mouse) 20430, (Rat) 308666
regulation of cell shape
Rac protein signal transduction
lamellipodium assembly
ruffle organization
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
axon extension
cognition
positive regulation of Arp2/3 complex-mediated actin nucleation
multicellular organism development
nervous system development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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