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Product Details
67264-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C5D5
Immunogen
CYP11A1 Fusion Protein Ag4353
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side chain cleavage; cholesterol side-chain cleavage cytochrome P450; Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; cytochrome P450 11a cholesterol side chain cleavage; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; Cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; P450(scc); steroid 20-22-lyase
Gene Aliases: cscc; CYP11A; Cyp11a-1; CYP11A1; CYPXIA1; D9Ertd411e; P450SCC; Scc
UniProt ID: (Human) P05108, (Rat) P14137, (Mouse) Q9QZ82
Entrez Gene ID: (Human) 1583, (Rat) 29680, (Mouse) 13070
iron ion binding
cholesterol monooxygenase (side-chain-cleaving) activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
cholesterol binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
organic acid metabolic process
steroid biosynthetic process
C21-steroid hormone biosynthetic process
progesterone biosynthetic process
estrogen biosynthetic process
response to nutrient
mating behavior
cholesterol metabolic process
male gonad development
response to salt stress
response to organic substance
response to ionizing radiation
response to gamma radiation
Schwann cell differentiation
response to organic cyclic compound
response to insecticide
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
cerebellum development
hippocampus development
response to vitamin E
Leydig cell differentiation
response to L-ascorbic acid
response to genistein
response to gonadotropin
response to drug
response to hydrogen peroxide
response to amino acid
response to alkaloid
response to peptide hormone
response to estrogen
cellular response to fibroblast growth factor stimulus
response to antibiotic
response to cadmium ion
response to steroid hormone
response to corticosterone
response to cAMP
oxidation-reduction process
granulosa cell differentiation
maternal process involved in female pregnancy
response to fungicide
testosterone biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to cadmium ion
cellular response to cAMP
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
glucocorticoid biosynthetic process
sterol metabolic process
cortisol metabolic process
vitamin D metabolic process
secondary metabolite biosynthetic process
lipid metabolic process
steroid metabolic process
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