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Product Details
PA5-99805
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human Cytochrome P450 11B2, corresponding to a region within the internal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2818738 |
Target Information
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYPXIB1; CYPXIB2; CYPXIB3; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P450(11 beta)-DS; P450-Aldo-1; P450-Aldo-2; P450C11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase
Gene Aliases: AA389061; ALDOS; Cp11ba; Cp45as; CPN1; CPN2; CYP11B; Cyp11b-1; Cyp11b-2; CYP11B1; CYP11B2; Cyp11b3; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; RATCP11BA; RNCP45AS; S11BH
UniProt ID: (Human) P15538, (Human) P19099, (Mouse) P15539
Entrez Gene ID: (Human) 1584, (Human) 1585, (Mouse) 110115, (Rat) 500892, (Mouse) 13072, (Rat) 24294
regulation of blood volume by renal aldosterone
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
aldosterone biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
oxidation-reduction process
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
steroid biosynthetic process
regulation of blood pressure
cortisol biosynthetic process
drinking behavior
positive regulation of blood pressure
ion homeostasis
response to nutrient
response to salt stress
cellular response to nutrient
response to insulin
cellular response to hormone stimulus
cellular response to potassium ion
response to drug
response to peptide hormone
cellular response to potassium ion starvation
cellular response to mechanical stimulus
cellular response to peptide hormone stimulus
renal water homeostasis
mineralocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
secondary metabolite biosynthetic process
immune response
glucose homeostasis
steroid metabolic process
glucocorticoid metabolic process
dibenzo-p-dioxin metabolic process
adenosine metabolic process
cellular response to interferon-gamma
response to dexamethasone
steroid 11-beta-monooxygenase activity
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
corticosterone 18-monooxygenase activity
steroid hydroxylase activity
steroid binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
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