|Western Blot (WB)||1:5000-1:20,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 13 and 366 of Human CYP17A1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27777 targets CYP17A1 in WB applications and shows reactivity with Human samples.
The PA5-27777 immunogen is recombinant fragment corresponding to a region within amino acids 13 and 366 of Human CYP17A1.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 17-alpha-hydroxyprogesterone aldolase; 17a-hydroxylase; 20 lyase; adrenal hyperplasia; CPT7; CYP17; CYPXVII; cytochrome P450; Cytochrome P450 17A1; cytochrome p450 XVIIA1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; Cytochrome P450-C17; Cytochrome P450c17; P450C17; S17AH; steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-monooxygenase; subfamily XVII (steroid 17-alpha-hydroxylase)
Gene Aliases: CPT7; CYP17; CYP17A1; P450C17; S17AH
UniProt ID: (Human) P05093
Entrez Gene ID: (Human) 1586
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