Abnova

CYP1B1 Recombinant Rabbit Monoclonal Antibody

View all (17) CYP1B1 antibodies

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Datasheet
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Datasheet
Protocols
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Datasheet
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Product Details

RAB02345

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to human CYP1B1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3710896

Target Information

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; CYPIB1; Cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); Cytochrome P450RAP; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450RAP; xenobiotic monooxygenase

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Gene Aliases: CP1B; CYP1B1; CYPIB1; GLC3A; P4501B1

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UniProt ID: (Human) Q16678, (Rat) Q64678

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Entrez Gene ID: (Human) 1545, (Rat) 25426

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Function(s)
monooxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase oxygenase metabolite interconversion enzyme
Process(es)
angiogenesis trabecular meshwork development cellular aromatic compound metabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion visual perception steroid metabolic process estrogen metabolic process negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance positive regulation of vascular endothelial growth factor production sterol metabolic process arachidonic acid metabolic process epoxygenase P450 pathway collagen fibril organization negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity negative regulation of cell adhesion mediated by integrin retinol metabolic process retinal metabolic process positive regulation of apoptotic process endothelial cell migration positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process blood vessel morphogenesis oxidation-reduction process retinal blood vessel morphogenesis cellular response to hydrogen peroxide cellular response to organic cyclic compound endothelial cell-cell adhesion omega-hydroxylase P450 pathway regulation of reactive oxygen species metabolic process DNA modification response to nutrient male gonad development response to organic substance response to organic cyclic compound positive regulation of smooth muscle cell migration dibenzo-p-dioxin metabolic process adrenal gland development response to follicle-stimulating hormone response to estradiol benzene-containing compound metabolic process estrous cycle positive regulation of translation response to arsenic-containing substance response to steroid hormone retina vasculature development in camera-type eye ganglion development cellular response to cAMP cellular response to tumor necrosis factor cellular response to luteinizing hormone stimulus cellular response to cortisol stimulus cellular response to progesterone stimulus response to dexamethasone response to indole-3-methanol positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process
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