The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP2C (CYPIIC) subfamily comprises a group of constitutively expressed genes, some phenobarbital-induced genes, and several genes associated with sex-specific expression. Originally, at least 7 genes were assigned to the CYP2C subfamily, which maps to human 10q24.1-q24.3 and mouse chromosome 19. Humans contain fewer genes in this cluster than do mice or rats. Four genes are arranged in the following order and orientation along human chromosome 10: RBP4, CYP2C18, CYP2C19/CYP2C9, and CYP2C8. The previsously identified CYP2C10 is an artifact of CYP2C9 and not a distinct isoform. All of the CYP2C proteins localize to the endoplasmic reticulum.
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Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; Cholesterol 25-hydroxylase; CPC9; CYP2C; CYP2C10; CYPIIC9; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; cytochrome P450, family 2, subfamily C, polypeptide 9; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; P450IIC9; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPC9; CYP2C; CYP2C10; CYP2C9; CYPIIC9; P450IIC9
UniProt ID: (Human) P11712
Entrez Gene ID: (Human) 1559