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Alomone Labs, LTD

CaV1.2 (CACNA1C) (extracellular) Polyclonal Antibody

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CaV1.2 (CACNA1C) (extracellular) Polyclonal Antibody

Product Details

ACC-130-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:300
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

2.5-5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide ERNMHQMTDGLDK, corresponding to amino acids residues 194-206 of rat GAT-1. Extracellular 2nd loop.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunogen sequence: ERNMHQMTDGLDK

Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain class C; CACH3; CACN4; CACNA 1D; CACNA1C intronic transcript 2; CACNA1C intronic transcript 2 (non-protein coding); CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; CaV1.2; DHP receptor; DHPR, alpha-1 subunit; ion channel; L-type calcium channel alpha-1 subunit; long-NT; LTCC; MGC120730; neuronal voltage-gated calcium channel alpha 1C subunit; RBC; skeletal muscle-specific calcium channel; unnamed protein product; voltage-dependent calcium channel; voltage-dependent L-type Ca2+ channel alpha 1 subunit; voltage-gated calcium channel subunit alpha Cav1.2

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Gene Aliases: CACH2; CACN2; CACNA1C-IT2; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; NEDHLSS; RATIVS302; TS; TS. LQT8

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UniProt ID: (Human) Q13936, (Mouse) Q01815, (Rat) P22002

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Entrez Gene ID: (Human) 775, (Mouse) 12288, (Rat) 24239

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Function(s)
ion channel activity voltage-gated calcium channel activity protein binding calmodulin binding high voltage-gated calcium channel activity alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential enzyme binding protein domain specific binding translation initiation factor binding ion channel binding protein phosphatase 2A binding
Process(es)
immune system development ion transport muscle contraction positive regulation of cytosolic calcium ion concentration heart development regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion embryonic forelimb morphogenesis camera-type eye development positive regulation of adenylate cyclase activity positive regulation of muscle contraction transmembrane transport calcium ion transport into cytosol cardiac conduction calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during AV node cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction calcium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential membrane depolarization during atrial cardiac muscle cell action potential system process calcium ion transport cellular calcium ion homeostasis exocytosis smooth muscle contraction cell communication chemical synaptic transmission adult walking behavior regulation of heart contraction regulation of blood pressure visual learning calcium ion regulated exocytosis regulation of vasoconstriction signaling insulin secretion growth hormone secretion positive regulation of insulin secretion positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of membrane potential glucose homeostasis regulation of organ growth smooth muscle contraction involved in micturition calcium ion import cell communication involved in cardiac conduction calcium ion transmembrane import into cytosol positive regulation of membrane depolarization positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel optic nerve development cerebral cortex development corpus callosum development response to nutrient levels axon development response to alcohol cellular response to beta-amyloid
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