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CaV2.3 (CACNA1E) Antibody (ACC-006-200UL) in IHC
Expression of CaV2.3 in mouse cerebellum - Immunohistochemical staining of mouse cerebellum with Anti-CaV2.3 (CACNA1E) Antibody (#ACC-006). CaV2.3 (red) appears in both soma and dendritic trees of several Purkinje cells. Staining of neurofilament 200 (green) in the same brain section demonstrates the relationship between axons passing through the granule layer and the Purkinje cells.
Product Details
ACC-006-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)SASQERSLDEGVSIDG, corresponding to amino acid residues 892-907 of rat CaV2.3, Intracellular loop between domains II and III
Conjugate
Form
Lyophilized
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA, 5% sucrose
Contains
0.025% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The expression of multiple classes of voltage dependent calcium channels (VDCCs) allows neurons to tailor calcium signaling to functionally discrete cellular regions. Although N-Type VDCCs exist before birth which is consistent with a role in migration, most N-Type VDCCs subunit expression is postnatal and is important in the genesis of synaptic transmission in discrete hippocampal fields.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BII; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; RBE-II; RBE2; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha 1E subunit; voltage-dependent calcium channel alpha1-E subunit; Voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel alpha subunit Cav2.3; Voltage-gated calcium channel subunit alpha Cav2.3
Gene Aliases: A430040I15; alpha1E; BII; CACH6; CACHA1E; CACNA1E; CACNL1A6; Cav2.3; Cchra1; gm139
UniProt ID: (Human) Q15878
Entrez Gene ID: (Human) 777, (Rat) 54234, (Mouse) 12290
transport
chemical synaptic transmission
regulation of ion transmembrane transport
regulation of insulin secretion
membrane depolarization
calcium ion transmembrane transport
membrane depolarization during action potential
behavioral fear response
regulation of heart rate
calcium ion transport
locomotory behavior
visual learning
transmission of nerve impulse
sensory perception of pain
sperm motility
glucose homeostasis
fear response
response to pain
behavioral response to pain
neurological system process
regulation of insulin secretion involved in cellular response to glucose stimulus
calcium ion import
regulation of somatostatin secretion
ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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