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|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Affinity purified, extracellular domain of human cadherin-11-GST fusion protein.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:50|
|Western Blot (WB)||1:25-1:250|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-06306 detects OB-cadherin in human and rat samples.
MA1-06306 has sucessfully been used in Western blotting, immunocytochemistry, and immunohistochemistry.
The MA1-06306 immunogen is affinity purified extracellular domain of human cadherin-11-GST fusion protein.
Store at 4°C, or in small aliquots at -20°C.
Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cadherin 11, type 2, OB-cadherin (osteoblast); Cadherin-11; OB-cadherin; OSF-4; Osteoblast Cadherin
CAD11; CDH11; CDHOB; OB; OSF-4