|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Radioimmune Assays (RIA)||Assay Dependent|
|Tested Species reactivity||Chemical|
|Host / Isotype||Mouse / IgG2b|
|Storage buffer||0.01M potassium phosphate with 0.135M NaCl, 2.5mM KCl, 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
MA5-14725 targets Caffeine in ELISA, IP, and RIA applications and shows reactivity with Chemical samples.
The MA5-14725 immunogen is caffeine-3-KLH.
Product MA514725 is a smaller package size of MIC0401 (formerly sold as a Seradyn product).
Caffeine is a methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity. [National Center for Biotechnology Information. PubChem Compound Database; CID=2519]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1,3,7-Trimethylxanthine; C8H10N4O2; Guaranine; Methyltheobromine
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