Recommended positive controls: Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, Molt-4, U87-MG, SK-N-SH, SK-N-AS, IMR32, JC, BCL-1, rat brain, human Calcineurin A-transfected 293T.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (90%), Xenopus laevis (98%), Dog (100%), Pig (99%), Rabbit (100%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
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Protein Aliases: calcineurin A alpha; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Aliases: 2900074D19Rik; CALN; CALNA; CALNA1; CCN1; CN; CNA; CNA1; PPP2B; PPP3CA
Molecular Function: protein phosphatase