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|Tested species reactivity||Human, Mouse, Rabbit, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||N-terminal extracellular region of the human Calcium Sensing Receptor .|
|Storage buffer||tris glycine with 0.15M NaCl|
|Contains||0.05% sodium azide|
|Storage Conditions||-20°C or -80°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 µg/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||1:50-1:200|
|Western Blot (WB)||1:50-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
Suggested positive control: antigen standard for CASR (transient overexpression lysate), human kidney protein.
The calcium-sensing receptor (CaSR) is an integral membrane protein that is a member of the G protein-coupled receptor family. It senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice.
MA1-16940 was used in immunohistochemistry - paraffin section to investigate how serotonin regulates calcium during lactation
|Laporta J,Keil KP,Vezina CM,Hernandez LL||PloS one (9:null)||2014|
calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaSR antibody; cation sensing receptor; extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; parathyroid Cell calcium-sensing receptor; parathyroid cell calcium-sensing receptor 1; Parathyroid Cell calcium-sensing receptor antibody.; PCaR1
CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1