PA5-29874 targets Calpain 10 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29874 immunogen is recombinant fragment corresponding to a region within amino acids 186 and 517 of Human Calpain 10.
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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: Calcium-activated neutral proteinase 10; Calpain-10; calpain-like protease CAPN10; CANP 10; CANP10; NIDDM1
Gene Aliases: CANP10; CAPN10; KIAA1845; NIDDM1
UniProt ID: (Human) Q9HC96
Entrez Gene ID: (Human) 11132