PA5-27721 targets Calpain 3 in WB applications and shows reactivity with Human samples.
The PA5-27721 immunogen is recombinant fragment corresponding to a region within amino acids 623 and 821 of Human Calpain 3.
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Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
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Protein Aliases: Calcium-activated neutral proteinase 3; calpain; calpain 3, (p94); Calpain L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CANP 3; CANP3; CANPL3; large [catalytic] subunit; large polypeptide L3; LGMD2; LGMD2A; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1
Gene Aliases: CANP3; CANPL3; CAPN3; LGMD2; LGMD2A; nCL-1; NCL1; p94
UniProt ID: (Human) P20807
Entrez Gene ID: (Human) 825