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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 623 and 821 of Human Calpain 3|
|Storage buffer||PBS, pH 7, with 40% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27721 targets Calpain 3 in WB applications and shows reactivity with Human samples.
The PA5-27721 immunogen is recombinant fragment corresponding to a region within amino acids 623 and 821 of Human Calpain 3.
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
calcium-activated neutral proteinase 3; calpain; calpain 3, (p94); calpain L3; calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; calpain-3; CANP3; CANPL3; large [catalytic] subunit; large polypeptide L3; LGMD2; LGMD2A; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; new calpain 1
CANP3; CANPL3; CAPN3; LGMD2; LGMD2A; nCL-1; NCL1; p94