This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
This antibody specifically recognizes the 28 to 30 kD small subunit of Calpain 1 and Calpain 2 (mu calpain and m calpain). It recognizes both native and denatured protein in ELISA, Western Blot and Immunoprecipitation.
The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and m-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, m-calpain is active at micromolar (mM) concentrations of Ca++. In addition to the ubiquitously expressed m- and m- calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit 2; calcium-dependent protease, small subunit; calpain 4, small subunit (30K); calpain II regulatory subunit; calpain II regulatory subunit (EC 188.8.131.52); Calpain regulatory subunit; Calpain small subunit 1; Calpain small subunit 2; calpain, small polypeptide; calpain, small subunit 1; calpain, small subunit 2; CANP small subunit; CDPS; CSS1; CSS2
Gene Aliases: CALPAIN4; CANP; CANPS; CAPN4; CAPNS; CAPNS1; CAPNS2; CDPS; CSS1