|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide derived from near the C-terminus of human Calponin-1|
|Storage buffer||tissue culture supernatant|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 2 publications below|
MA5-14464 targets Calponin-1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-14464 immunogen is a synthetic peptide derived from near the C-terminus of human Calponin-1.
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Comparison of estrogen receptor-¿, progesterone receptor and calponin expression in gonadotrophin-releasing hormone agonist-sensitive and -resistant uterine fibroids.
MA5-14464 was used in immunohistochemistry to study GnRH agonist-sensitive and -resistant uterine fibroids to determine if ER-alpha, PR and calponin are differentially expressed
|Kim EH,Kim JY,Lee YH,Chong GO,Park JY,Hong DG||Obstetrics and gynecology science (57:144)||2014|
Multinodular reticular schwannoma in the head and neck region: a potential diagnostic pitfall.
MA5-14464 was used in immunohistochemistry to report on a case of multinodular reticular schwannoma in the head and neck region
|Lau PP,Yau DT,Lau WH,Mak LS,Chan JK||International journal of surgical pathology (21:54)||2013|