In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) CA2 and rhCA3 is observed and less than 1% cross-reactivity with rhCA1, rhCA4, and rhCA9 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
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Protein Aliases: CA-related protein; CA-VIII; carbonate dehydratase; Carbonic anhydrase VIII; carbonic anhydrase-like sequence; Carbonic anhydrase-related protein; CARP; MGC120502; MGC99509
Gene Aliases: CA-RP; CA-VIII; CA8; CALS; CAMRQ3; CARP
UniProt ID: (Human) P35219
Entrez Gene ID: (Human) 767