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Immunofluorescent analysis of Carboxylesterase 2 showing staining in the cytoplasm of HepG2 cells. HepG2 cells were fixed in ice-cold MeOH for 5 min and stained using a Carboxylesterase 2 polyclonal antibody (Product # PA5-28027) diluted at 1:500. Blue: Hoechst 33342 staining.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 51 and 469 of Human Carboxylesterase 2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28027 targets Carboxylesterase 2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28027 immunogen is recombinant fragment corresponding to a region within amino acids 51 and 469 of Human Carboxylesterase 2.
Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
carboxylesterase 2 (intestine, liver); CE-2, CES2A1, PCE-2, iCE, carboxylesterase 2 (intestine, liver), cocaine esterase, hCE-2, intestinal carboxylesterase; hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; liver carboxylesterase-2, methylumbelliferyl-acetate deacetylase 2; methylumbelliferyl-acetate deacetylase 2
CE-2; CES2; CES2A1; ICE; PCE-2