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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified, full length, native human protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-25767 detects Carboxypeptidase B2 from human samples.
MA1-25767 has been successfully used in Western blot procedures.
The MA1-25767 immunogen is purified, full length, native human protein.
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Value of α-methylacyl-CoA racemase immunochemistry for predicting neoplastic progression in Barrett's oesophagus.
MA1-25767 was used in immunohistochemistry to study the predictive value of the immunohistochemical expression of alpha-methylacyl-CoA recemase in Barratt's oesophagus
|Kastelein F,Biermann K,Steyerberg EW,Verheij J,Kalisvaart M,Looijenga LH,Stoop HA,Walter L,Kuipers EJ,Spaander MC,Bruno MJ||Histopathology (63:630)||2013|
carboxypeptidase B-like protein; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase R; CPU; PCPB; TAFI; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
CPB2; CPU; PCPB; TAFI