This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
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Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: CARBE; CPE; CPH; Cph-1; Cph1; fat; R74677