In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) CPA1, recombinant mouse CPA4 and rhCPB1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
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Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: CPE; CPH
UniProt ID: (Human) P16870
Entrez Gene ID: (Human) 1363